Clinical significance of microcytosis in patients with primary myelofibrosis

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Treatment options for patients with primary myelofibrosis

Background Primary myelofibrosis (PMF) is a myeloproliferative disorder resulting in progressive bone marrow fibrosis. In some PMF patients, a mutation in the gene coding for janus-associated kinase 2 (JAK2) results in cell proliferation and evasion of apoptosis. PMF typically occurs in older patients, and is associated with poor prognosis and low survival, with death occurring secondary to car...

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Molecular Pathogenesis and Clinical Significance of Driver Mutations in Primary Myelofibrosis: A Review

Primary myelofibrosis (PMF) is a rare chronic BCR-ABL1-negative myeloproliferative neoplasm characterized by progressive bone marrow fibrosis, inefficient hematopoiesis, and shortened survival. The clinical manifestations of PMF include splenomegaly, consequent to extramedullary hematopoiesis, pancytopenias, and an array of potentially debilitating constitutional symptoms. The diagnosis is base...

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ژورنال

عنوان ژورنال: Leukemia Research

سال: 2014

ISSN: 0145-2126

DOI: 10.1016/j.leukres.2014.08.007