Clinical significance of microcytosis in patients with primary myelofibrosis
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چکیده
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15 صفحه اولTreatment options for patients with primary myelofibrosis
Background Primary myelofibrosis (PMF) is a myeloproliferative disorder resulting in progressive bone marrow fibrosis. In some PMF patients, a mutation in the gene coding for janus-associated kinase 2 (JAK2) results in cell proliferation and evasion of apoptosis. PMF typically occurs in older patients, and is associated with poor prognosis and low survival, with death occurring secondary to car...
متن کاملMolecular Pathogenesis and Clinical Significance of Driver Mutations in Primary Myelofibrosis: A Review
Primary myelofibrosis (PMF) is a rare chronic BCR-ABL1-negative myeloproliferative neoplasm characterized by progressive bone marrow fibrosis, inefficient hematopoiesis, and shortened survival. The clinical manifestations of PMF include splenomegaly, consequent to extramedullary hematopoiesis, pancytopenias, and an array of potentially debilitating constitutional symptoms. The diagnosis is base...
متن کاملThe Clinical Significance of IDH Mutations in Essential Thrombocythemia and Primary Myelofibrosis
BACKGROUND Limited data exist regarding impact of IDH mutations in Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPNs). Prognostic significance of IDH mutations was asessed in 184 Ph-negative MPN patients - 107 essential thrombocythemia (ET) and 77 primary myelofibrosis (PMF). METHODS High-resolution melting (HRM) analysis was used to detect IDH1 and IDH2 mutations. RESULT...
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ژورنال
عنوان ژورنال: Leukemia Research
سال: 2014
ISSN: 0145-2126
DOI: 10.1016/j.leukres.2014.08.007